"guys, we are sixty-four handles lower on the day here, guys. . ."

from Fear Index by Robert Harris

It's the price without any decimals. So if something is trading at 50.65, its "handle" is 50. Something which dropped from 1064.57 to 1000.86 dropped 64 handles.

"guys, we are sixty-four handles lower on the day here, guys. . ."

from Fear Index by Robert Harris